Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (26)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ohe, Y.
Right arrow Articles by Nishiwaki, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ohe, Y.
Right arrow Articles by Nishiwaki, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Annals of Oncology 15:45-50, 2004
© 2004 European Society for Medical Oncology

Original Paper

A phase II study of cisplatin and docetaxel administered as three consecutive weekly infusions for advanced non-small-cell lung cancer in elderly patients

Received 20 April 2003; revised 17 August 2003; accepted 28 August 2003

Background:

To evaluate the efficacy and safety of treatments for advanced non-small-cell lung cancer in elderly patients aged 75 years or older, we conducted a phase II study of cisplatin and docetaxel administered in three consecutive weekly infusions.

Patients and methods:

The eligibility criteria for the study included the presence of chemotherapy-naive advanced non-small-cell lung cancer, age ≥75 years, Eastern Cooperative Oncology Group performance status of 0 or 1, a measurable lesion, adequate organ functions and signed informed consent. The chemotherapy regimen consisted of cisplatin (25 mg/m2) and docetaxel (20 mg/m2) on days 1, 8 and 15 every 4 weeks.

Results:

Between February 2000 and March 2002, 34 elderly patients with non-small-cell lung cancer were enrolled in the study and 33 patients were treated. Two complete responses and 15 partial responses were obtained for an objective response rate of 52% in 33 treated patients. The median survival period was 15.8 months, and the 1-year survival rate was 64%. Toxicities were mild with no grade 4 toxicities. Only grade 3 leukopenia (6%), neutropenia (12%), anemia (3%), hyponatremia (3%) and nausea/vomiting (3%) were observed.

Conclusion:

Cisplatin and docetaxel administered in three consecutive weekly infusions was safe and effective for the treatment of elderly patients with chemotherapy-naive non-small-cell lung cancer.

Y. Ohe1,*, S. Niho2, R. Kakinuma2, K. Kubota2, H. Ohmatsu2, K. Goto2, H. Nokihara1, H. Kunitoh1, N. Saijo1, H. Aono3, K. Watanabe3, M. Tango4, A. Yokoyama4 and Y. Nishiwaki2

1 Department of Internal Medicine, National Cancer Center Hospital, Tokyo; 2 Division of Thoracic Oncology, National Cancer Center Hospital, Kashiwa City; 3 Division of Respiratory Medicine, Yokohama Municipal Citizen’s Hospital, Yokohama; 4 Department of Internal Medicine, Niigata Cancer Center Hospital, Niigata, Japan

Key words: cisplatin, docetaxel, elderly patients, non-small-cell lung cancer, weekly administration


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 The OncologistHome page
S. S. Ramalingam and F. R. Khuri
The Role of the Taxanes in the Treatment of Older Patients with Advanced Stage Non-Small Cell Lung Cancer
Oncologist, April 1, 2009; 14(4): 412 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Am Soc Clin Oncol Ed BookHome page
C. Gridelli, P. Maione, and A. Rossi
Chemotherapy and Targeted Therapy for Older Patients with Advanced Non-small Cell Lung Cancer
ASCO Educational Book, January 1, 2009; 2009(1): 283 - 287.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. Gridelli, P. Maione, A. Illiano, F. V. Piantedosi, A. Favaretto, A. Bearz, S. F. Robbiati, V. Filipazzi, V. Lorusso, F. Carrozza, et al.
Cisplatin Plus Gemcitabine or Vinorelbine for Elderly Patients With Advanced Non Small-Cell Lung Cancer: The MILES-2P Studies
J. Clin. Oncol., October 10, 2007; 25(29): 4663 - 4669.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. Gridelli, C. Langer, P. Maione, A. Rossi, and S. E. Schild
Lung Cancer in the Elderly
J. Clin. Oncol., May 10, 2007; 25(14): 1898 - 1907.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Hurria, M. T. Fleming, S. D. Baker, Wm. K. Kelly, K. Cutchall, K. Panageas, J. Caravelli, H. Yeung, M. G. Kris, J. Gomez, et al.
Pharmacokinetics and toxicity of weekly docetaxel in older patients.
Clin. Cancer Res., October 15, 2006; 12(20): 6100 - 6105.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. Kudoh, K. Takeda, K. Nakagawa, M. Takada, N. Katakami, K. Matsui, T. Shinkai, T. Sawa, I. Goto, H. Semba, et al.
Phase III Study of Docetaxel Compared With Vinorelbine in Elderly Patients With Advanced Non-Small-Cell Lung Cancer: Results of the West Japan Thoracic Oncology Group Trial (WJTOG 9904)
J. Clin. Oncol., August 1, 2006; 24(22): 3657 - 3663.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Gridelli and F. A. Shepherd
Chemotherapy for Elderly Patients With Non-Small Cell Lung Cancer: A Review of the Evidence
Chest, August 1, 2005; 128(2): 947 - 957.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. Gridelli, M. Aapro, A. Ardizzoni, L. Balducci, F. De Marinis, K. Kelly, T. Le Chevalier, C. Manegold, F. Perrone, R. Rosell, et al.
Treatment of Advanced Non-Small-Cell Lung Cancer in the Elderly: Results of an International Expert Panel
J. Clin. Oncol., May 1, 2005; 23(13): 3125 - 3137.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
I. Okamoto, E. Moriyama, S. Fujii, H. Kishi, M. Nomura, E. Goto, C. Kiyofuji, F. Imamura, T. Mori, and M. Matsumoto
Phase II Study of Carboplatin-Paclitaxel Combination Chemotherapy in Elderly Patients with Advanced Non-small Cell Lung Cancer
Jpn. J. Clin. Oncol., April 1, 2005; 35(4): 188 - 194.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.