Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (14)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Park, S. H.
Right arrow Articles by Kang, W. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Park, S. H.
Right arrow Articles by Kang, W. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Annals of Oncology 14:1373-1377, 2003
© 2003 European Society for Medical Oncology

Original Paper

Postoperative chemoradiotherapy for gastric cancer

S. H. Park1,+, D. Y. Kim1, J. S. Heo3, D. H. Lim2, C. K. Park4, K. W. Lee3, S. H. Choi3, T. S. Sohn3, S. Kim3, J. H. Noh3, Y. I. Kim3, J. O. Park1, K. Kim1, W. S. Kim1, C. W. Jung1, Y. H. Im1, M. H. Lee1, K. Park1, C. H. Park5,6 and W. K. Kang1,§

Division of Hematology and Oncology, Departments of 1 Medicine, 2 Radiation Oncology, 3 Surgery and 4 Diagnostic Pathology, 5 Cancer Center, Samsung Medical Center, Sunkyunkwan University School of Medicine, Seoul, Korea; 6 The Center for the Improvement of Human Functioning International, Inc., Wichita, KS, USA

Received 19 February 2003; revised 16 April 2003; accepted 14 May 2003

Background:

We report the results of postoperative chemoradiotherapy after curative resection in gastric cancer patients.

Patients and methods:

Patients with gastric cancer staged IB to IV(M0) were treated with chemoradiotherapy after curative resection with extensive (D2) lymph node dissection. Nodal metastases were observed in 261 (90%) patients. The chemotherapy consisted of fluorouracil 400 mg/m2 plus leucovorin 20 mg/m2 for 5 days, followed by 4500 cGy of radiotherapy for 5 weeks with fluorouracil and leucovorin on the first 4 days and the last 3 days of radiotherapy. Two 5-day cycles of chemotherapy were given 4 weeks after the completion of radiotherapy.

Results:

Of 290 patients accrued, 229 (79%) patients completed chemoradiotherapy as planned. With a median follow-up of 49 months, 114 (34%) patients have relapsed: 33 (29%) locoregional relapses, 76 (67%) peritoneal relapses and 41 (36%) distant metastases. The 5-year overall and relapse-free survivals were 60% and 57%, respectively. Tolerance was acceptable, the main toxicity being neutropenia.

Conclusions:

This postoperative chemoradiotherapy after curative resection of gastric cancer was feasible, with acceptable toxicities. Whether this adjuvant therapy in gastric cancer patients that have undergone a D2 lymph node dissection impacts on survival or reduces the incidence of relapses remains to be studied.

Key words: adenocarcinoma, chemoradiotherapy, gastric, postoperative


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann OncolHome page
F. Bozzetti
Postoperative chemoradiotherapy after curative gastrectomy for cancer
Ann. Onc., February 1, 2004; 15(2): 356 - 356.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.