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Annals of Oncology 14:1341-1345, 2003
© 2003 European Society for Medical Oncology

Hepatitis C and B-cell lymphoma

N. C. Turner1, G. Dusheiko1 and A. Jones1,+

1 Department of Clinical Oncology and 2Centre for Hepatology, Royal Free and University College Medical School, London, UK

Received 4 September 2002; revised 27 January 2003; accepted 14 March 2003

Abstract

The association between the hepatitis C virus and B-cell non-Hodgkin’s lymphomas is controversial. We review the epidemiological evidence behind the association, and look at the reasons behind the variation in study findings. There is increasing evidence of the pathogenesis of hepatitis C-associated lymphoma. Treatment of the hepatitis C virus with antiviral therapy may lead to the regression of some low-grade lymphomas. The management of other hepatitis C-associated lymphomas is similar to that of conventional lymphoma, although viral reactivation and subsequent immune reconstitution hepatitis can complicate chemotherapy.

Key words: hepatitis C, lymphoma, pathogenesis


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