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Annals of Oncology 14:1253-1257, 2003
© 2003 European Society for Medical Oncology

Original Paper

Phase II study of neo-adjuvant chemotherapy with paclitaxel and cisplatin given every 2 weeks for patients with a resectable squamous cell carcinoma of the esophagus

M. B. Polee1,+, H. W. Tilanus2, F. A. L. M. Eskens1, R. Hoekstra1, M. E. L. Van der Burg1, P. D. Siersema3, G. Stoter1 and A. Van der Gaast1

1 Departments of 2 Medical Oncology, 3 Surgery and Gastroenterology and Hepatology, Erasmus Medical Centre, Rotterdam, The Netherlands

Received 11 February 2003; accepted 8 April 2003

Background:

We have previously reported a favourable response rate in patients with advanced esophageal cancer after treatment with a biweekly regimen of paclitaxel and cisplatin. In this study we investigate the feasibility and efficacy of this regimen in a neo-adjuvant setting.

Patients and methods:

Patients with resectable squamous cell carcinoma of the esophagus received paclit-axel 180 mg/m2 and cisplatin 60 mg/m2 every 2 weeks. Patients received three courses and responding patients received three additional courses; thereafter, patients were referred for surgery. Patient characteristics of 50 eligible patients were as follows: male, 60%; median age, 62 years (range 45–78); median World Health Organization performance status of 1 (range 0–2).

Results:

Ninety-four per cent of patients received at least three courses of chemotherapy. Haematological toxicity consisted of National Cancer Institute–Common Toxicity Criteria grade 3 or 4 neutropenia in 71% of patients, with neutropenic fever occurring in only two patients (4%). The overall response rate was 59%. Pathological examination showed tumour-free margins in 38 patients. In seven patients no residual tumour was found. The median overall survival was 20 months and the 1- and 3-year survival rates were 68% and 30%, respectively.

Conclusions:

This dose-dense schedule of paclitaxel and cisplatin administered biweekly is well tolerated and the observed overall and complete response rates are promising.

Key words: biweekly, cisplatin, esophageal cancer, neo-adjuvant, paclitaxel


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