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Annals of Oncology 14:333-337, 2003
© 2003 European Society for Medical Oncology

Clinical Investigations

Taxane-induced nail changes: incidence, clinical presentation and outcome

A. M. Minisini1, A. Tosti2, A. F. Sobrero3, M. Mansutti4, B. M. Piraccini2, C. Sacco4 and F. Puglisi1,+

1 Clinical Oncology, University of Udine, Udine; 2 Department of Dermatology, University of Bologna, Bologna; 3 Clinical Oncology, San Martino Hospital, Genoa; 4 Clinical Oncology, General Hospital, Udine, Italy

Received 5 June 2002; accepted 3 July 2002

Abstract

The clinical characteristics of nail changes in seven patients receiving taxane-containing chemotherapy are described. They include nail pigmentation, subungual hematoma, Beau’s lines and onycholysis and subungual suppuration.

The incidence of such changes (ranging from 0% to 44%) is reviewed from a Medline search of the literature.

Key words: chemotherapy, nail changes, side-effects, taxanes


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