Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Morice, P.
Right arrow Articles by Castaigne, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morice, P.
Right arrow Articles by Castaigne, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Annals of Oncology 14:1511-1517, 2003
© 2003 European Society for Medical Oncology

Original Paper

Prognostic value of lymphovascular space invasion determined with hematoxylin–eosin staining in early stage cervical carcinoma: results of a multivariate analysis

P. Morice1,+, P. Piovesan1, A. Rey2, D. Atallah1, C. Haie-Meder3, P. Pautier4, L. Sideris1, C. Pomel1, P. Duvillard5 and D. Castaigne1

Departments of 1 Surgery, 2 Biostatistics, 3 Radiation Therapy and 4 Medical Oncology, 5 Pathology, Institut Gustave Roussy, Villejuif, France

Received 6 February 2003; revised 9 May 2003; accepted 17 June 2003

Background:

Our aim was to study the prognostic value of the presence of lymphovascular space invasion (LVSI) in patients with stage IB and II cervical carcinoma treated by initial surgery.

Patients and methods:

A retrospective analysis was performed on 193 patients who underwent, between 1985 and 1998, an initial radical hysterectomy with pelvic (± para-aortic) lymphadenectomy using midline laparotomy for stage IB (180 patients) or II (13 patients) cervical carcinoma. Postoperative therapy was delivered according to prognostic factors.

Results:

The rate of LVSI correlated significantly with tumor stage, nodal status and the location of positive nodes. Using univariate analysis, tumor size (<4 or >=4 cm), LVS status and nodal status were prognostic factors. At multivariate analysis, two prognostic factors were identified: LVS status and nodal status. In a subgroup of 89 patients with a small tumor (<=2 cm) and absence of nodal or isthmic involvement, the overall survival was significantly correlated with the presence of LVSI.

Conclusions:

LVSI is a frequent occurrence in patients with early stage cervical cancer. It represents an unfavorable prognostic factor in univariate and multivariate analyses. Such results suggest that improvement is needed in the treatment of patients with a small tumor and LVS invasion.

Key words: cervical cancer, multivariate analysis, nodal involvement, vascular space invasion


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 In VivoHome page
P. ZARGANIS, A. KONDI-PAFITI, P. ARAPANTONI-DADIOTI, E. TRIVIZAKI, K. VELENTZAS, G. VORGIAS, and S. FOTIOU
The Sentinel Node in Cervical Cancer Patients: Role of Tumor Size and Invasion of Lymphatic Vascular Space
In Vivo, May 1, 2009; 23(3): 469 - 473.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. S. Sundar and T. S. Ganesan
Role of Lymphangiogenesis in Cancer
J. Clin. Oncol., September 20, 2007; 25(27): 4298 - 4307.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. Gabriel, A. zur Hausen, E. Stickeler, C. Dietz, G. Gitsch, D.-C. Fischer, J. Bouda, C. Tempfer, and A. Hasenburg
Weak Expression of Focal Adhesion Kinase (pp125FAK) in Patients with Cervical Cancer Is Associated with Poor Disease Outcome
Clin. Cancer Res., April 15, 2006; 12(8): 2476 - 2483.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.