Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (40)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Santini, D.
Right arrow Articles by Tonini, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Santini, D.
Right arrow Articles by Tonini, G.
Related Collections
Right arrow 2003 - Review Articles
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Annals of Oncology 14:1468-1476, 2003
© 2003 European Society for Medical Oncology

The antineoplastic role of bisphosphonates: from basic research to clinical evidence

D. Santini1,+, U. Vespasiani Gentilucci2, B. Vincenzi1, A. Picardi2, F. Vasaturo3, A. La Cesa1, N. Onori4, S. Scarpa3 and G. Tonini1

Interdisciplinary Center for Biomedical Research (CIR), 1 Oncology, 2 Laboratory of Internal Medicine and Hepathology and 4 Clinical Pharmacology, University Campus Bio-Medico, Rome; 3 Department of Experimental Medicine and Pathology, ‘La Sapienza’ University, Rome, Italy

Received 19 December 2002; revised 7 March 2003; accepted 14 April 2003

Abstract

Bisphosphonates are now well established as successful agents for the prevention and treatment of postmenopausal osteoporosis, corticosteroid-induced bone loss and Paget’s disease. Bisphosphonates have also recently become important in the management of cancer-induced bone disease, and they now have a widely recognized role for patients with multiple myeloma and bone metastases secondary to breast cancer and prostate cancer. Recent studies suggest that, besides the strong antiosteoclastic activity, the efficacy of such compounds in the oncological setting could also be due also to direct antitumor effect, exerted at different levels. Here, after a brief analysis of the chemical structure, we will review the antineoplastic and biological properties of bisphosphonates. We will start from well estabilished mechanisms of action and go on to discuss the latest evidence and hypotheses. In particular, we will review the antiresorptive properties in malignant osteolysis and the recent evidence of a direct antitumor effect. Furthermore, this review will analyze the influence of bisphosphonates on cancer growth factor release, their effect on cancer cell adhesion, invasion and viability, the proapoptotic potential on cancer cells, the antiangiogenic effect, and, finally, the immunomodulating properties of bisphosphonates on the {gamma}{delta} T cell population.

Key words: angiogenesis, antineoplastic, apoptosis, bisphosphonates, clinical and preclinical evidence


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
G. T. Stathopoulos, C. Moschos, H. Loutrari, A. Kollintza, I. Psallidas, S. Karabela, S. Magkouta, Z. Zhou, S. A. Papiris, C. Roussos, et al.
Zoledronic Acid Is Effective against Experimental Malignant Pleural Effusion
Am. J. Respir. Crit. Care Med., July 1, 2008; 178(1): 50 - 59.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Santini, B. Vincenzi, S. Galluzzo, F. Battistoni, L. Rocci, O. Venditti, G. Schiavon, S. Angeletti, F. Uzzalli, M. Caraglia, et al.
Repeated Intermittent Low-Dose Therapy with Zoledronic Acid Induces an Early, Sustained, and Long-Lasting Decrease of Peripheral Vascular Endothelial Growth Factor Levels in Cancer Patients
Clin. Cancer Res., August 1, 2007; 13(15): 4482 - 4486.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
T. Van den Wyngaert, M. T. Huizing, and J. B. Vermorken
Bisphosphonates and osteonecrosis of the jaw: cause and effect or a post hoc fallacy?
Ann. Onc., August 1, 2006; 17(8): 1197 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
S.-B. Woo, J. W. Hellstein, and J. R. Kalmar
Systematic Review: Bisphosphonates and Osteonecrosis of the Jaws
Ann Intern Med, May 16, 2006; 144(10): 753 - 761.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Gao, H. Deng, H. Zhao, A. Hirbe, J. Harding, L. Ratner, and K. Weilbaecher
HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition
Blood, December 15, 2005; 106(13): 4294 - 4302.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.