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Annals of Oncology 14:9-19, 2003
© 2003 European Society for Medical Oncology

Evidence-based management options for women at increased breast/ovarian cancer risk

G. Pichert+, B. Bolliger, K. Buser and O. Pagani On behalf of the Swiss Institute for Applied Cancer Research Network for Cancer Predisposition Testing and Counseling

Division of Oncology, Department of Medicine, University Hospital, Zürich, Switzerland

Received 26 April 2002; revised 29 July 2002; accepted 27 August 2002

Abstract

Recent developments in our ability to predict breast cancer risk necessitates primary care physicians learn to evaluate breast cancer risk and its importance in shaping decisions concerning surveillance and risk reduction measures. This article reviews the current opinion on risk assessment and management of women with an increased risk of breast/ovarian cancer. Management options are given for women at slightly, moderately and highly elevated breast cancer risk, as well as for BRCA1/2 carriers, based on currently available evidence.

Key words: BRCA1, BRCA2, familial risk, hereditary breast cancer, ovarian cancer, prophylactic surgery


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