Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (19)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Levi, F.
Right arrow Articles by La Vecchia, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Levi, F.
Right arrow Articles by La Vecchia, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Annals of Oncology 14:71-73, 2003
© 2003 European Society for Medical Oncology

Original Paper

Cancer risk in women with previous breast cancer

F. Levi1,2,+, V.-C. Te1, L. Randimbison1 and C. La Vecchia1,3,4

1 Cancer Epidemiology Unit and Cancer Registry of Vaud, Institut Universitaire de Médecine Sociale et Préventive, Lausanne; 2 Cancer Registry of Neuchâtel, Neuchâtel, Switzerland; 3 Laboratory of Epidemiology, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan; 4 Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy

Received 5 August 2002; accepted 28 August 2002

Background:

Excess risks of several second neoplasms following breast cancer have been reported. However, these risks have still to be quantified.

Patients and methods:

We considered 9729 breast cancer patients registered by the Swiss Cancer Registries of Vaud and Neuchâtel (covering about 786 000 inhabitants) and followed up from 1974 to 1998.

Results:

Overall, 443 second primary neoplasms (other than second primary breast cancers) were observed versus 389 expected [standardised incidence ratio (SIR): 1.14; 95% confidence interval (CI) 1.04–1.25]. The SIRs were above unity for endometrium (SIR = 1.5), ovary (1.3), colorectum (1.1), gallbladder (1.4), cutaneous malignant melanoma (1.4), kidney (1.4), lymphomas (1.4) and leukaemias (1.2), as well as for selected tobacco-related neoplasms. The largest excess risk was found for soft tissue sarcomas (STS) with 10 cases observed versus 3.1 expected (SIR = 3.2; 95% CI 1.5–5.9). Of these, eight occurred in potentially irradiated areas.

Conclusions:

This analysis confirms the existence of a modest excess in several neoplasms occurring after breast cancer. The substantial excess of STS confirms the strong association between irradiation and STS.

Key words: breast cancer, follow-up study, population-based, second primary cancer, soft-tissue sarcoma, standardised incidence ratio


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mayo Clin Proc.Home page
S. N. Markovic, L. A. Erickson, R. D. Rao, R. R. McWilliams, L. A. Kottschade, E. T. Creagan, R. H. Weenig, J. L. Hand, M. R. Pittelkow, B. A. Pockaj, et al.
Malignant Melanoma in the 21st Century, Part 1: Epidemiology, Risk Factors, Screening, Prevention, and Diagnosis
Mayo Clin. Proc., March 1, 2007; 82(3): 364 - 380.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
G. Pruneri, S. Cinieri, F. Peccatori, and G. Viale
Unusual Cases in Multiple Myeloma and a Dramatic Response in Metastatic Lung Cancer: CASE 2. Plasma Cell Myeloma Coexisting With Metastatic Breast Carcinoma in the Bone Marrow
J. Clin. Oncol., January 1, 2005; 23(1): 232 - 233.
[Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
T. Koga, Y. Horio, T. Mitsudomi, T. Takahashi, and Y. Yatabe
Identification of MGB1 as a Marker in the Differential Diagnosis of Lung Tumors in Patients with a History of Breast Cancer by Analysis of Publicly Available SAGE Data
J. Mol. Diagn., May 1, 2004; 6(2): 90 - 95.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.