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Annals of Oncology 14:20-28, 2003
© 2003 European Society for Medical Oncology

The Snark is a Boojum: the continuing problem of drug resistance in the antiangiogenic era

K. D. Miller+, C. J. Sweeney and G. W. Sledge

Division of Hematology and Oncology, Indiana University, Indianapolis, USA

Received 18 July 2002; accepted 13 September 2002

Abstract

If your Snark be a Snark, that is right:

Fetch it home by all means—you may serve it with greens,

And it’s handy for striking a light . . .

"But oh, beamish nephew, beware of the day,

If your Snark be a Boojum! For then

You will softly and suddenly vanish away,

And never be met with again!"

Lewis Carroll

The Hunting of the Snark

Key words: angiogenesis, drug resistance, endothelial cells, growth factors


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