Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Germann, N.
Right arrow Articles by Goldwasser, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Germann, N.
Right arrow Articles by Goldwasser, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Annals of Oncology 13:632-636, 2001
© 2001 European Society for Medical Oncology

Clinical Investigations

The chemotherapy of metastatic gastric adenocarcinomas with hypersecretion of {alpha}-fetoprotein or ß-human chorionic gonadotrophin: report of two cases

N. Germann1, M. Gross-Goupil1, E. Wasserman1, J.-F. Emile2, J.-L. Misset1, M. Reynes2 and F. Goldwasser1,+

1Service de Cancérologie and 2Laboratoire d’Anatomopathologie, Hôpital Paul Brousse, Villejuif, France

Received 9 January 2001; revised and accepted 11 June 2001.

Abstract

The chemotherapy of advanced gastric adenocarcinomas (GAs) is based on agents such as cisplatin, 5-fluorouracil and anthracyclins. Reproducible objective response rates are reported as ~40%. However, the median survival remains short, not exceeding 10 months. Amongst GA, a subset of tumours with increased plasma {alpha}-fetoprotein ({alpha}FP) and/or ß human chorionic gonadotrophin (ßHCG) levels form a well-defined histopathological entity. This subgroup has been associated with poor prognosis, due to the presence of poorly differentiated and rapidly proliferating cells. No specific chemotherapy has been proposed for this particular form of GA. We report two cases of patients with GA and hypersecretion of {alpha}FP and/or ßHCG. Despite bulky liver metastases and resistance to two standard chemotherapy regimens, both patients exhibited sensitivity to chemotherapy combining bleomycin, oxaliplatin and etoposide. These results suggest that patients with this particular subset of GA may benefit from chemotherapy regimens similar to those given to germ-cell tumour patients.

Key words: adenocarcinoma, {alpha}-fetoprotein, ß human chorionic gonadotrophin, chemotherapy, gastric


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.