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Annals of Oncology 13:480-481, 2002
© 2002 European Society for Medical Oncology

Clinical Investigations

Anaphylactic shock secondary to intravenous administration of folinic acid: a first report

M. Benchalal1, E. Yahchouchy-Chouillard2, S. Fouere3 and A. Fingerhut2,+

1Oncology and 2Digestive Surgery Departments, Centre Hospitalier Intercommunal de Poissy-Saint Germain, Poissy Cedex; 3Dermatology Department, Hôpital Saint-Louis, France

Received 16 May 2001; accepted 5 June 2001.

Abstract

Background

Folates, components of the B-complex vitamins, have numerous pharmacological effects. In oncology combining folates with 5-fluorouracil (5-FU) enhances the cytotoxic effects of chemotherapy in colon cancer patients. Folic acid has been rarely involved in adverse allergic reactions. To the best of our knowledge no anaphylactic reaction secondary to folinic acid (FA) administration has ever been reported before.

Patients and methods

An 80-year-old patient had adjuvant chemotherapy for colon cancer including FA and 5-FU and irinotecan as a second line agent after multiple metastases.

Results

Following FA administration anaphylactic shock occurred. Diagnosis was made according to the French method of adverse reactions monitoring.

Conclusion

Anaphylactic shock may be an adverse reaction of FA in patients receiving chemotherapy for colon cancer.

Key words: adverse reaction, anaphylactic shock, chemotherapy, colon cancer, folinic acid


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