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Annals of Oncology 13:1806-1809, 2002
© 2002 European Society for Medical Oncology

Original Paper

Use of a topoisomerase I inhibitor (irinotecan, CPT-11) in metastatic adrenocortical carcinoma

E. Baudin1,+, C. Docao1, C. Gicquel2, G. Vassal3, A. Bachelot1, A. Penfornis4 and M. Schlumberger1

1 Service de Médecine Nucléaire et de Cancérologie Endocrinienne, Institut Gustave-Roussy, Villejuif; 2 Laboratoire d’Explorations Fonctionnelles Endocriniennes, Hôpital Armand Trousseau, Paris; 3 Département de Pédiatrie et Laboratoire de Pharmacotoxicologie et Pharmacogénétique, Institut Gustave-Roussy, Villejuif; 4 Service d’Endocrinologie, Centre Hospitalier et Universitaire de Besançon, Besançon, France

Received 7 May 2002; accepted 22 May 2002

Background:

Complete responses are rare after medical treatment of adrenocortical tumors. We performed a single center prospective study of the antitumor effect of irinotecan (CPT-11) in patients with metastatic adrenocortical cancer.

Patients and methods:

Since 1999, all patients with advanced progressive adrenocortical carcinoma, referred to the Institut Gustave-Roussy, have been enrolled prospectively in this study. CPT-11 (250 mg/m2) was administered intravenously on day 1 in a 2-h infusion, every 14 days. World Health Organization (WHO) criteria were used to evaluate tumor response and toxicity.

Results:

During treatment, no dose or schedule modifications were made. A median of three courses were given (range 1–8), and all but two patients received at least three complete chemotherapy courses. No objective or complete responses were observed. The best response achieved was stabilization in three patients, lasting from 1.5 to 4 months. Significant toxicity occurred in two patients.

Conclusions:

Our results do not support a major role of CPT-11 in adrenocortical carcinoma.

Key words: adrenocortical carcinoma, chemotherapy, CPT-11, irinotecan


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