{gamma}{delta} T-cell neoplasms: a clinicopathological study of 11 cases

doi:10.1093/annonc/mdf293

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Annals of Oncology 13:1792-1798, 2002
© 2002 European Society for Medical Oncology

Original Paper

${gamma}$ ${delta}$ T-cell neoplasms: a clinicopathological study of 11 cases

T. Saito¹, Y. Matsuno², R. Tanosaki¹, T. Watanabe¹, Y. Kobayashi¹ and K. Tobinai¹^,+

¹ Hematology Division and ² Clinical Laboratory Division, National Cancer Center Hospital, Tsukiji, Chuo-ku, Tokyo, Japan

Received 25 October 2001; revised 21 March 2002; accepted 10 April 2002

Background:

The majority of T-cell neoplasms express T-cell antigen receptor(TCR) ${alpha}$ ß on their cell surface, and a few cases showthe TCR ${gamma}$ ${delta}$ phenotype. Recently, a variety of ${gamma}$ ${delta}$ T-cell neoplasmwas recognized; however, its clinicopathological features havenot been extensively analyzed. Here we report the results ofa clinicopathological study of 11 cases of ${gamma}$ ${delta}$ T-cell neoplasm.

Patients and methods:

During the 11-year period from 1989 to 1999, 104 patients withT-cell neoplasms were examined by flow cytometric analysis and/orimmunohistochemical analysis. Tumor cells from all 104 patientsexpressed one or more of the T-cell antigens—CD2, CD3,CD5 and CD7. Forty-nine of the 104 cases of T-cell neoplasmswere examined immunophenotypically for TCR ${alpha}$ ß/ ${gamma}$ ${delta}$ subsets.

Results:

Expression of TCR ${gamma}$ ${delta}$ on tumor cells was found in five (33%) of15 patients with precursor T-cell lymphoblastic leukemia/lymphoma,one (25%) of four with T-cell granular lymphocytic leukemiaand five (26%) of 19 with peripheral T-cell lymphoma (PTCL),whereas no expression was found in 11 patients with adult T-cellleukemia-lymphoma. Primary sites of the five patients with ${gamma}$ ${delta}$ PTCL were as follows: lymph node, three; skin, one and liver,tonsil and skin, one. The courses of the three patients with ${gamma}$ ${delta}$ PTCL of nodal onset were very short (3, 5 and 9 months, respectively),and they were all resistant to combination chemotherapies.

Conclusions:

Although ${gamma}$ ${delta}$ T-cell neoplasm constitutes a heterogeneous population,it is important to examine the expression of TCR with the viewto identifying possible poor prognostic subgroups, such as primarynodal ${gamma}$ ${delta}$ T-cell lymphoma.

Key words: ${gamma}$ ${delta}$ T-cell neoplasm, nodal ${gamma}$ ${delta}$ T-cell lymphoma, T-cell receptor

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