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Annals of Oncology 13:1598-1604, 2002
© 2002 European Society for Medical Oncology

Original Paper

Clinical implications of expression of ETS-1 related to angiogenesis in uterine cervical cancers

J. Fujimoto+, I. Aoki, H. Toyoki, S. Khatun and T. Tamaya

Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan

Received 6 November 2001; revised 18 February 2002; accepted 26 March 2002

Background:

Angiogenesis is essential for development, growth and advancement of solid tumors. ETS-1 has been recognized as a candidate for tumor angiogenic transcription factor. This prompted us to study the clinical implications of ETS-1-related angiogenesis in uterine cervical cancers.

Patients and methods:

Fifty patients underwent curative resection for uterine cervical cancers. The patients’ prognoses were analyzed with a 24-month survival rate. In the tissue of 60 uterine cervical cancers, the levels of ets-1 mRNA, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), platelet-derived endothelial cell growth factor (PD-ECGF) and interleukin (IL)-8 were determined by competitive reverse transcription–polymerase chain reaction using recombinant RNA and enzyme immunoassay, and the localization and counts of microvessels were determined by immunohistochemistry.

Results:

There was a significant correlation between microvessel counts and ets-1 gene expression levels in uterine cervical cancers. Immunohistochemical staining revealed that the localization of ETS-1 was similar to that of vascular endothelial cells. The level of ets-1 mRNA correlated with the levels of PD-ECGF and IL-8 among angiogenic factors. Furthermore, the prognosis of the 25 patients with high ets-1 mRNA expression in uterine cervical cancers was extremely poor, while the 24-month survival rate of the other 25 patients with low ets-1 mRNA expression was 92%.

Conclusions:

ETS-1 might be a prognostic indicator as an angiogenic mediator in uterine cervical cancers.

Key words: angiogenesis, ets-1, IL-8, PD-ECGF, uterine cervical cancer


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