Annals of Oncology

This Article FREE Full Text (PDF) E-letters: Submit a response Alert me when this article is cited Alert me when E-letters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Personal Archive Download to citation manager Search for citing articles in: ISI Web of Science (107) Request Permissions Disclaimer Google Scholar Articles by Waldherr, C. Articles by Mueller-Brand, J. Search for Related Content PubMed PubMed Citation Articles by Waldherr, C. Articles by Mueller-Brand, J. Social Bookmarking          What's this?

Annals of Oncology 12:941-945, 2001
© 2001 European Society for Medical Oncology

research-article

The clinical value of [⁹⁰Y-DOTA]-D-Phe¹-Tyr³-octreotide (⁹⁰Y-DOTATOC) in the treatment of neuroendocrine tumours: A clinical phase II study

C. Waldherr^1,, M. Pless², H. R. Maecke³, A. Haldemann⁴ and J. Mueller-Brand¹

¹Department of Nuclear Medicine with PET-Center Bellinzona, Switzerland
²Department of Oncology Bellinzona, Switzerland
³Department of Radiopharmacy, University Hospital, Basel Bellinzona, Switzerland
⁴Oncology Institute of Southern Switzerland Bellinzona, Switzerland

Dr C. Waldherr University Hospital Basel Department of Clinical Nuclear Medicine School of Medicine Petersgraben 4 4031 Basel Switzerland E-mail: cwaldherr{at}uhbs.ch

Purpose: The aim of this phase II study was to evaluate the tumour response of neuroendocrine tumours to targeted irradiation with the radiolabelled somatostatin analogue ⁹⁰Y-DOTATOC. In addition, the palliative effect of ⁹⁰-Y-DO-TATOC treatment on the malignant carcinoid syndrome and tumour-associated pain was investigated.

Patients and methods: Forty-one patients (mean age 53 years) with neuroendocrine gastroenteropancreatic and bronchial tumours were included. Eighty-two percent of the patients had therapy resistant and progressive disease. The treatment con sisted of four intravenous injections ofa total of 6000 MBq/m^{2 90}Y-DOTATOC, administered at intervals of six weeks.

Results:The overall response rate was 24%. For endocrine pancreatic tumours it was 36%. Complete remissions (CR) were found in 2% (1 of 41), partial remissions (PR) in 22% (9 of 41), minor response in 12% (5 of 41), stable disease (SD) in 49% (20 of4l) and progressive disease (PD) in 15% (6 of4l). The median follow up was 15 months (range 1 month to 36 months). The median duration of response has not been reached at 26 months. The two-year survival time was 76 ± 16%. Eighty-three percent of the patients suffering from the malignant carcinoid syndrome achieved a significant reduction of symptoms. The treatment was well tolerated. A reduction of pain score was observed in all patients (5 of 41) with morphine dependent tumour-associated pain. Side effects included grade LU (NCIGC) pancytopenia in 5%, and vomiting shortly after injection in 23%. No grade III—IV renal toxicity was observed.

Conclusion: Targeted radiotherapy with ⁹⁰Y-DOTATOC is a novel, well-tolerated treatment for neuroendocrine turnours with a remarkable objective response rate, survival time, and symptomatic response.

endocrine pancreatic tumour, neuroendocrine tumour, octreotide, radionuclide therapy, somatostatine analogue

CiteULike    Connotea    Del.icio.us    What's this?

This article has been cited by other articles:

				J. B. Cwikla, A. Sankowski, N. Seklecka, J. R. Buscombe, A. Nasierowska-Guttmejer, K. G. Jeziorski, R. Mikolajczak, D. Pawlak, K. Stepien, and J. Walecki Efficacy of radionuclide treatment DOTATATE Y-90 in patients with progressive metastatic gastroenteropancreatic neuroendocrine carcinomas (GEP-NETs): a phase II study Ann. Onc., October 15, 2009; (2009) mdp372v1. [Abstract] [Full Text] [PDF]

				B. W. Wessels, M. W. Konijnenberg, R. G. Dale, H. B. Breitz, M. Cremonesi, R. F. Meredith, A. J. Green, L. G. Bouchet, A. B. Brill, W. E. Bolch, et al. MIRD Pamphlet No. 20: The Effect of Model Assumptions on Kidney Dosimetry and Response--Implications for Radionuclide Therapy J. Nucl. Med., November 1, 2008; 49(11): 1884 - 1899. [Abstract] [Full Text] [PDF]

				S. Grozinsky-Glasberg, I. Shimon, M. Korbonits, and A. B Grossman Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanisms Endocr. Relat. Cancer, September 1, 2008; 15(3): 701 - 720. [Abstract] [Full Text] [PDF]

				M. Miederer, G. Henriksen, A. Alke, I. Mossbrugger, L. Quintanilla-Martinez, R. Senekowitsch-Schmidtke, and M. Essler Preclinical Evaluation of the {alpha}-Particle Generator Nuclide 225Ac for Somatostatin Receptor Radiotherapy of Neuroendocrine Tumors Clin. Cancer Res., June 1, 2008; 14(11): 3555 - 3561. [Abstract] [Full Text] [PDF]

				D. J. Kwekkeboom, W. W. de Herder, B. L. Kam, C. H. van Eijck, M. van Essen, P. P. Kooij, R. A. Feelders, M. O. van Aken, and E. P. Krenning Treatment With the Radiolabeled Somatostatin Analog [177Lu-DOTA0,Tyr3]Octreotate: Toxicity, Efficacy, and Survival J. Clin. Oncol., May 1, 2008; 26(13): 2124 - 2130. [Abstract] [Full Text] [PDF]

				F. Iten, B. Muller, C. Schindler, C. Rochlitz, D. Oertli, H. R. Macke, J. Muller-Brand, and M. A. Walter Response to [90Yttrium-DOTA]-TOC Treatment is Associated with Long-term Survival Benefit in Metastasized Medullary Thyroid Cancer: A Phase II Clinical Trial Clin. Cancer Res., November 15, 2007; 13(22): 6696 - 6702. [Abstract] [Full Text] [PDF]

				D. Cornelio, R Roesler, and G Schwartsmann Gastrin-releasing peptide receptor as a molecular target in experimental anticancer therapy Ann. Onc., September 1, 2007; 18(9): 1457 - 1466. [Abstract] [Full Text] [PDF]

				W. A. Weber Positron Emission Tomography As an Imaging Biomarker J. Clin. Oncol., July 10, 2006; 24(20): 3282 - 3292. [Abstract] [Full Text] [PDF]

				S. Kneifel, D. Cordier, S. Good, M. C.S. Ionescu, A. Ghaffari, S. Hofer, M. Kretzschmar, M. Tolnay, C. Apostolidis, B. Waser, et al. Local Targeting of Malignant Gliomas by the Diffusible Peptidic Vector 1,4,7,10-Tetraazacyclododecane-1-Glutaric Acid-4,7,10-Triacetic Acid-Substance P. Clin. Cancer Res., June 15, 2006; 12(12): 3843 - 3850. [Abstract] [Full Text] [PDF]

				G. Vitale, W. W. de Herder, P. M. van Koetsveld, M. Waaijers, W. Schoordijk, E. Croze, A. Colao, S. W.J. Lamberts, and L. J. Hofland IFN-{beta} Is a Highly Potent Inhibitor of Gastroenteropancreatic Neuroendocrine Tumor Cell Growth In vitro Cancer Res., January 1, 2006; 66(1): 554 - 562. [Abstract] [Full Text] [PDF]

				A. Capello, E. P. Krenning, B. F. Bernard, W. A.P. Breeman, J. L. Erion, and M. de Jong Anticancer Activity of Targeted Proapoptotic Peptides J. Nucl. Med., January 1, 2006; 47(1): 122 - 129. [Abstract] [Full Text] [PDF]

				G A Kaltsas, D Papadogias, P Makras, and A B Grossman Treatment of advanced neuroendocrine tumours with radiolabelled somatostatin analogues Endocr. Relat. Cancer, December 1, 2005; 12(4): 683 - 699. [Abstract] [Full Text] [PDF]

				S. M. Verwijnen, E. P. Krenning, R. Valkema, J. G.M. Huijmans, and M. de Jong Oral Versus Intravenous Administration of Lysine: Equal Effectiveness in Reduction of Renal Uptake of [111In-DTPA]Octreotide J. Nucl. Med., December 1, 2005; 46(12): 2057 - 2060. [Abstract] [Full Text] [PDF]

				M. de Jong, R. Barone, E. Krenning, B. Bernard, M. Melis, T. Visser, M. Gekle, T. E. Willnow, S. Walrand, F. Jamar, et al. Megalin Is Essential for Renal Proximal Tubule Reabsorption of 111In-DTPA-Octreotide J. Nucl. Med., October 1, 2005; 46(10): 1696 - 1700. [Abstract] [Full Text] [PDF]

				F. Forrer, H. Uusijarvi, D. Storch, H. R. Maecke, and J. Mueller-Brand Treatment with 177Lu-DOTATOC of Patients with Relapse of Neuroendocrine Tumors After Treatment with 90Y-DOTATOC J. Nucl. Med., August 1, 2005; 46(8): 1310 - 1316. [Abstract] [Full Text] [PDF]

				D. J. Kwekkeboom, J. J. Teunissen, W. H. Bakker, P. P. Kooij, W. W. de Herder, R. A. Feelders, C. H. van Eijck, J.-P. Esser, B. L. Kam, and E. P. Krenning Radiolabeled Somatostatin Analog [177Lu-DOTA0,Tyr3]Octreotate in Patients With Endocrine Gastroenteropancreatic Tumors J. Clin. Oncol., April 20, 2005; 23(12): 2754 - 2762. [Abstract] [Full Text] [PDF]

				M. Ginj, J. Chen, M. A. Walter, V. Eltschinger, J. C. Reubi, and H. R. Maecke Preclinical Evaluation of New and Highly Potent Analogues of Octreotide for Predictive Imaging and Targeted Radiotherapy Clin. Cancer Res., February 1, 2005; 11(3): 1136 - 1145. [Abstract] [Full Text] [PDF]

				M. de Jong, W. A.P. Breeman, R. Valkema, B. F. Bernard, and E. P. Krenning Combination Radionuclide Therapy Using 177Lu- and 90Y-Labeled Somatostatin Analogs J. Nucl. Med., January 1, 2005; 46(1_suppl): 13S - 17S. [Abstract] [Full Text] [PDF]

				D. J. Kwekkeboom, J. Mueller-Brand, G. Paganelli, L. B. Anthony, S. Pauwels, L. K. Kvols, T. M. O'Dorisio, R. Valkema, L. Bodei, M. Chinol, et al. Overview of Results of Peptide Receptor Radionuclide Therapy with 3 Radiolabeled Somatostatin Analogs J. Nucl. Med., January 1, 2005; 46(1_suppl): 62S - 66S. [Abstract] [Full Text] [PDF]

				J. C. Reubi, H. R. Macke, and E. P. Krenning Candidates for Peptide Receptor Radiotherapy Today and in the Future J. Nucl. Med., January 1, 2005; 46(1_suppl): 67S - 75S. [Abstract] [Full Text] [PDF]

				R. Valkema, S. A. Pauwels, L. K. Kvols, D. J. Kwekkeboom, F. Jamar, M. de Jong, R. Barone, S. Walrand, P. P.M. Kooij, W. H. Bakker, et al. Long-Term Follow-Up of Renal Function After Peptide Receptor Radiation Therapy with 90Y-DOTA0,Tyr3-Octreotide and 177Lu-DOTA0, Tyr3-Octreotate J. Nucl. Med., January 1, 2005; 46(1_suppl): 83S - 91S. [Abstract] [Full Text] [PDF]

				S. J. Goldsmith Improving Insight into Radiobiology and Radionuclide Therapy J. Nucl. Med., July 1, 2004; 45(7): 1104 - 1105. [Full Text] [PDF]

				M. de Jong, R. Valkema, A. van Gameren, H. van Boven, A. Bex, E. P. van de Weyer, J. D. Burggraaf, M. Korner, J.-C. Reubi, and E. P. Krenning Inhomogeneous Localization of Radioactivity in the Human Kidney After Injection of [111In-DTPA]Octreotide J. Nucl. Med., July 1, 2004; 45(7): 1168 - 1171. [Abstract] [Full Text] [PDF]

				G. A. Kaltsas, G. M. Besser, and A. B. Grossman The Diagnosis and Medical Management of Advanced Neuroendocrine Tumors Endocr. Rev., June 1, 2004; 25(3): 458 - 511. [Abstract] [Full Text] [PDF]

				J. C. Reubi Peptide Receptors as Molecular Targets for Cancer Diagnosis and Therapy Endocr. Rev., August 1, 2003; 24(4): 389 - 427. [Abstract] [Full Text] [PDF]

				S. Palm, R. M. Enmon Jr., C. Matei, K. S. Kolbert, S. Xu, P. B. Zanzonico, R. L. Finn, J. A. Koutcher, S. M. Larson, and G. Sgouros Pharmacokinetics and Biodistribution of 86Y-Trastuzumab for 90Y Dosimetry in an Ovarian Carcinoma Model: Correlative MicroPET and MRI J. Nucl. Med., July 1, 2003; 44(7): 1148 - 1155. [Abstract] [Full Text] [PDF]

				L. J. Hofland and S. W. J. Lamberts The Pathophysiological Consequences of Somatostatin Receptor Internalization and Resistance Endocr. Rev., February 1, 2003; 24(1): 28 - 47. [Abstract] [Full Text] [PDF]

				M. d. Jong and E. Krenning New Advances in Peptide Receptor Radionuclide Therapy J. Nucl. Med., May 1, 2002; 43(5): 617 - 620. [Full Text] [PDF]

Online ISSN 1569-8041 - Print ISSN 0923-7534

Copyright © 2009 European Society for Medical Oncology

Oxford Journals Oxford University Press

• Site Map
• Privacy Policy
• Frequently Asked Questions

Other Oxford University Press sites: Oxford University Press Oxford Journals China Oxford Journals Japan American National Biography Booksellers' Information Service Children's Fiction and Poetry Children's Reference Corporate & Special Sales Dictionaries Dictionary of National Biography Digital Reference English Language Teaching Higher Education Textbooks Humanities International Education Unit Law Medicine Music Online Products Oxford English Dictionary Reference Rights and Permissions Science School Books Social Sciences Very Short Introductions World's Classics