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Annals of Oncology 12:895-908, 2001
© 2001 European Society for Medical Oncology


review-article

Cancer genetics in oncology practice

O. I. Olopade1, and G. Pichert2

1University of Chicago Pritzker School of Medicine Chicago, Illinois, USA
2Department of Medicine, University Hospital Zurich, Switzerland

O.L. Olopade, MD Section of Hematology/Oncology Center for Clinical Cancer Genetics University of Chicago MC2115. 5841 S. Maryland Ave Chicago, IL 60637 USA E-mail folopade{at}medicine.bsd.uchicago.edu

Cancer is a genetic disease caused by the progressive accumulation of mutations in critical genes that control cell growth and differentiation. Completion of the Human Genome Project promises to revolutionize the practice of Medicine, especially Oncology care. The tremendous gains in the knowledge of the structure and function of human genes will surely impact the diagnosis, prognosis and treatment of cancer. Moreover, it will lead to more effective cancer control through the use of genetics to quantify individual cancer risks. This article reviews the current status of genetic testing and counseling for cancer risk assessment and will suggest a framework for integrating such counseling into oncology practice.

BRCA1, BRCA2, cancer genetics, cancer screening, familial risks, FAP, genetic counseling, HNPCC, prevention


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