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Annals of Oncology 12:1005-1010, 2001
© 2001 European Society for Medical Oncology

research-article

Primary non-Hodgkin's lymphomas of the liver with nodular and diffuse infiltration patterns have different prognoses

J.-F. Emile1,, D. Azoulay2, J.-M. Gornet3, G. Lopes3, V. Delvart2, D. Samuel2, M. Reynes1, H. Bismuth2 and F. Goldwasser3

1Service d'anatomie parthologtque Hôpital Paul Brousse, UPRES 1596 and IFR 89, Universite Pairs, France
2Centre hepatobiliaire Hôpital Paul Brousse, UPRES 1596 and IFR 89, Universite Pairs, France Hôpital Paul Brousse, UPRES 1596 and IFR 89, Universite Pairs, France
3Fédération des services maladies sanguines immuntairese Hôpital Paul Brousse, UPRES 1596 and IFR 89, Universite Pairs, France

J.-F. Emile. MD, PhD Service d'anatomopathologie Hôpital Paul Brousse BP200 94804 Villejuif Cedex France E-mail: jean-francois.emile{at}pbr.ap-hop-paris.fr

Background Primary liver non-Hodgkin's lymphomas have peculiar clinical and biological patterns. This study correlates these patterns with pathology and outcome.

Patients and methods: Clinical records and histology of patients with primary liver non-Hodgkin's lymphoma, treated at our institution over a 20-year period, were reviewed. Lymphoproliferations occurring after liver transplantation were excluded. Survival analyses were performed with patients from the other published series (62 patients).

Results: Our series included eight patients, Three patients had a nodular liver infiltration, corresponding to a large B-cell lymphoma. Five patients had a diffuse liver infiltration, of whom three had a 1-cell lymphorna with predominant sinusoid infiltration, and two had a large B-cell lymphoma. Patients with diffuse liver infiltration presented with hepatomegaly, and two of these also had acute liver failure. Diffuse infiltration had a worse prognosis than nodular infiltration (P=0.0033). Among these latter patients, those treated with an anthracyclin based chemotherapy had a better outcome (P < 0.0001)

Conclusions: Patients with primary liver lymphomas can be classified in two groups, depending on the type of infiltration. Those with nodular infiltration may benefit from anthracyclin based chemotherapy. Diffuse infiltration has a bad prognosis. and should be suspected in patients presenting with altered liver functions and hepatomegaly.

anthracyclin, hepatomegaly, liver, lymphoma


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