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Annals of Oncology 12:275-276, 2001
© 2001 European Society for Medical Oncology

case-report

Complete response of an HIV negative gastric Kaposi's sarcoma (KS) patient with peritoneal carcinomatosis by liposomal daunorubicin treatment

A. Fléchon1,2, C. Lombard-Bohas1,2,, J. Boulez2, J.-Y. Blay1 and J.-Y. Scoazec3

1Oncologie Médicale Lyon, France
2Fédération des Spécialités digestives Lyon, France
3Laboratoire d'Anatomie et de Cytologie Pathologiques, Hôpital Edouard Herriot Lyon, France

Unité Fonctionnelle d'Oncologie Médicale Fédération des Spécialités digestives Pavillon O. Hôpital Edouard Herriot 5 place d'Arsonval 69437 Lyon cedex 03 France

We report the first case of an HIV negative patient with gastric Kaposi's sarcoma (KS) and peritoneal carcinomatosis in whom a complete response (CR) was obtained after liposomal daunorubicin administration. The patient presented with epigastric pain and hematemesis. Upper gastric endoscopy with multiple biopsies showed gastric involvement by KS. The whole physical examination and the thoraco-abdomino-pelvic CT scans showed no other localization. A total gastrectomy was performed. Histological examination confirmed the diagnosis of KS with involvement of regional lymph nodes and peritoneal lesions. Six cycles of liposornal daunorubicin were given. Post-treatment coelioscopic control was normal. The patient received another six adjuvant cycles of liposomal daunorubicin. The patient is in complete remission six months after the end of treatment. Liposomal daunorubicin is a promising treatment in the non HIV patient with visceral KS.

gastric, Kaposi's sarcoma, liposomal daunorubicin, peritoneal carcinomatosis


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