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Annals of Oncology 12:1761-1763, 2001
© 2001 European Society for Medical Oncology

other

Hand-foot syndrome associated with short infusions of combination chemotherapy with gemcitabine and vinorelbine

E. Laack, T. Mende, C. Knuffmann and D. K. Hossfeld

Clinic for Internal Medecine, Department of Oncology and Hematology, University Hospital Hamburg-Eppendorf Hamburg Germany

E Laack, MD, Clinic for Internal Medecine, Department of Oncology and Hematology, University Hospital Hamburg-Eppendorf Martinistrasse 52 20246 Hamburg, Germany E-mail: laack{at}uke.uni-hamburg.de

The hand-foot syndrome (palmar-plantar erythrodysesthesia) is a side-effect which is associated with several cytotoxic agents (e.g. 5-fluorouracil, UFT, capecitabine, cytarabine, doxorubicin, liposomal-encapsulated doxorubicin). An association with a prolonged infusion of high doses of vinorelbine has also been described. To date a hand-foot syndrome after gemcitabine or short infusions of vinorelbine has not been reported before. The patient described here had a non-small-cell lung cancer stage IIIB disease and developed a hand-foot syndrome after short infusions of standard-dose chemotherapy of a combination with gemcitabine and vinorelbine.

chemotherapy, gemcitabine, hand-foot syndrome, non-small-cell lung cancer, vinorelbine


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