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Annals of Oncology 11:S69-S73, 2000
© 2000 European Society for Medical Oncology

Symposium Articles

Non-Hodgkin's lymphoma and occupational exposure to chemicals in Canada

Y. Mao, J. Hu, A.-M. Ugnat, K. White for the Canadian Cancer Registries Epidemiology Research Group

Cancer Bureau, Laboratory Centre for Disease Control, Health Protection Branch, Health Canada Ottawa, Ontario, Canada

Correspondence to: Dr Y. Mao, MD Division of Environmental Risk Assessment and Case Surveillance Cancer Bureau, Laboratory Centre for Disease Control, Address locator 0601C1, Ottawa, Ontario, K1A 0L2 Canada E-mail: Yang.Mao{at}hc-sc.gc.ca

Background: The incidence of non-Hodgkin's lymphoma (NHL) has been increasing in Canada. This study assessed the effect of occupational exposure to specific chemicals on the risk of NHL.

Patients and methods: Mailed questionnaires were used to obtain data on 1469 newly diagnosed, histologically confirmed NHL cases and 5073 population controls between 1994 and 1997 in eight Canadian provinces. Data was collected on socioeconomic status, life-style, diet, occupation, and years of exposure to any of 17 chemicals. Odds ratios (OR) and 95% confidence intervals (95% CI) were derived by logistic regression.

Results: The study found an increased risk of NHL among males exposed to benzidine, mineral, cutting, or lubricating oil, pesticides, and herbicides. Compared with non-exposure to each specific chemical, the adjusted ORs were 1.9 (95% CI: 1.1–3.4) for benzidine, 1.3 (95% CI: 1.0–1.5) for mineral, cutting, or lubricating oil, 1.3 (95% CI: 1.0–1.6) for herbicides, and 1.3 (95% CI: 1.0–1.6) for pesticides. Excess risk of NHL among females was associated with exposure to pesticides and wood dust. ORs increased with increasing exposure in years to benzidine and herbicides for males and with increasing exposure years to wood dust for females. These trends were statistically significant (P<0.05).

Conclusions: The findings in this study suggest that occupational exposure to specific chemicals plays an important role in the development of NHL in Canada.

chemicals, non-Hodgkin's lymphoma, occupational exposure, odds ratio


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