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Annals of Oncology 11:1551-1556, 2000
© 2000 European Society for Medical Oncology

research-article

Follicular large cell lymphoma: Long-term follow-up of 62 patients treated between 1973–1981

J. Rodriguez, P. McLaughlin, L. Fayad, M. Santiago, M. Hess, M. A. Rodriguez, J. Romaguera, F. Hagemeister, H. Kantarjian and F. Cabanillas

University of Texas M.D. Anderson Cancer Center Houston, Texas, USA

Correspondence to: P. McLaughlin, MD University of Texas M.D. Anderson Cancer Center 1515 Holcombe Blvd. Box 68 Houston, TX 77030 USA

Purpose: Investigators disagree on whether follicular large cell lymphoma (FLCL) behaves like other follicular lymphomas, with no plateau in the survival curve, or as a more aggressive but potentially curable lymphoma. We reported in 1984 results for 62 FLCL patients treated at our institution; the current report updates those results.

Patients and methods: Sixty-two patients referred from 1973–1981, including fifteen (24%) patients with Ann Arbor stage I-II and forty-seven (76%) with stage III-IV FLCL. Seven patients received radiation (XRT) alone, forty patients XRT and chemotherapy, and fifteen patients received chemotherapy alone.

Results: The median follow-up was 14.7 years. The median survival was 5.1 years, with 21% alive at 15 years. The failure-free survival (FFS) at 10 years was 31%. Univariate analysis revealed that age, Ann Arbor stage, and the International Index correlated with survival. Performance status, number of platelets, and LDH correlated with failure-free survival.

Conclusions: FLCL responds to doxorubicin-based regimens similarly to diffuse large cell lymphoma. Patients with FLCL have the potential for prolonged failure-free survival. Variables that predict the survival in aggressive lymphomas apply as well in this type of lymphoma.

follicle center lymphoma, follicular, follicular large cell lymphoma, follicular lymphoma, grade 3


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