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Annals of Oncology 10:S9-S15, 1999
© 1999 European Society for Medical Oncology

Symposium Articles

Clinicopathological profile as a basis for classification of the endocrine tumours of the gastroenteropancreatic tract

E. Solcia1,2, G. Rindi1,2, D. Paolotti1, S. La Rosa3, C. Capella3 and R. Fiocca4

1 Department of Human Pathology, University of Pavia
2 IRCCS Policlinico San Matteo Pavia
3 Department of Clinical and Biological Sciences, University of Insubria Varese
4 Institute of Pathologic Anatomy, University of Genova Italy

Correspondence to: Prof. E. Solcia, Dipartimento di Patologia Umana Sezione di Anatomia Patologica via Forlanini, 16 1-27100 Pavia, Italy

Recent developments in the field of endocrine cell biology and pathology, at both morphologic and molecular levels, are briefly outlined and discussed as a basis for endocrine tumour characterization. The main clinicopathological tools available for the identification and characterization of endocrine tumours are discussed. Based on this, classifications of endocrine tumours of the pancreas and gastrointestinal tract are developed covering most clinical (hyperfunctional syndromes included), pathologic and biological patterns and with special emphasis on tumour prognosis.

classification, endocrine tumours, histochemistry, molecular biology, pathology


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