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Annals of Oncology 1:227-228, 1990
© 1990 European Society for Medical Oncology

other

Effectiveness and low toxicity of hepatic artery infusion with fluorouracil and mitomycin for metastatic colorectal cancer confined to the liver

M. Borner1,, U. Laffer2, C. Ludwig1, R. Obrist1, U. Metzger3, P. Aeberhard4, W. Weber5, M. Castiglione6, J.P. Obrecht1, K. Brunner6, F. Gloor7, F. Cavalli8, H.J. Senn9 and From the Swiss Group for Clinical and Epidemiological Cancer Research (SAKK)

1Division of Oncology, Departement of Internal Medicine Kantonsspital, Basel
2Department of Surgery Kantonsspital, Basel
3Department of Surgery, Universitätsspital Zürich;
4Department of Surgery Kantonsspital, Aarau
5Medical Oncology, Private Practice Basel
6Institute of Medical Oncology, University of Bern Inselspital, Bern
7Institute of Pathology Kantonsspital, St. Gallen
8Division of Oncology Ospedale San Giovanni, Bellinzona
9Chairman of the SAKK, Division of Oncology and Hematology Kantonsspital, St. Gallen, Switzerland

Correspondence to: M. Borner, M.D. SAKK Konsumstrasse 13 CH-3007 Bern, Switzerland

The usefulness of hepatic artery infusion (HAI) with floxuridine is limited by the severe biliary and hepatic toxicity of floxuridine. This prompted the SAKK to evaluate the effectiveness, toxicity and feasibility of HAI with fluorouracil (FU) and mitomycin (MMC) administered by an external portable pump. Of 28 patients treated, partial responses were obtained in 14 (50%, 95% confidence interval: 30% to 70%) and stabilization in 11 (39%, 21% to 60%), for a median duration of 12.6+ months. Median survival was 19.5+ months. Grade I–II toxicity (WHO) consisted of nausea (46%), leucopenia (32%) thrombocytopenia (21%) and abdominal discomfort (25%). Two patients developed gastro-duodenal ulcers and two others grade III leucopenia. No life-threatening side effects, especially no sclerosing cholangitis or chemical hepatitis, were observed. In conclusion, HAI with FU and MMC is a valid alternative to floxuridine HAI in metastatic colorectal cancer confined to the liver.

colorectal cancer, fluorouracil, hepatic artery infusion, mitomycin


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